HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

Host cells impose a broad range of obstacles to the replication of retroviruses. Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells. HIV-1 Vpu efficiently counteracts this restriction. Here, we show that HIV-1 Vpu ind...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mangeat, Bastien, Gers-Huber, Gustavo, Lehmann, Martin, Zufferey, Madeleine, Luban, Jeremy, Piguet, Vincent
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2009
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729927/
https://ncbi.nlm.nih.gov/pubmed/19730691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000574
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