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Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism

The primary roles attributed to the human immunodeficiency virus type 1 (HIV-1) Vpu protein are the degradation of the viral receptor CD4 and the enhancement of virion release. With regard to CD4 downregulation, Vpu has been shown to act as an adapter linking CD4 with the ubiquitin-proteasome machin...

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Detalhes bibliográficos
Main Authors: Douglas, Janet L., Viswanathan, Kasinath, McCarroll, Matthew N., Gustin, Jean K., Früh, Klaus, Moses, Ashlee V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715753/
https://ncbi.nlm.nih.gov/pubmed/19515779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00242-09
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