Pharmacological Targeting of Native CatSper Channels Reveals a Required Role in Maintenance of Sperm Hyperactivation

The four sperm-specific CatSper ion channel proteins are required for hyperactivated motility and male fertility, and for Ca(2+) entry evoked by alkaline depolarization. In the absence of external Ca(2+), Na(+) carries current through CatSper channels in voltage-clamped sperm. Here we show that CatS...

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Main Authors: Carlson, Anne E., Burnett, Lindsey A., del Camino, Donato, Quill, Timothy A., Hille, Bertil, Chong, Jayhong A., Moran, Magdalene M., Babcock, Donner F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729922/
https://ncbi.nlm.nih.gov/pubmed/19718436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006844
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