Genotyping of Frequent BRCA1/2 SNPs with Unlabeled Probes: A Supplement to HRMCA Mutation Scanning, Allowing the Strong Reduction of Sequencing Burden

We previously validated mutation scanning for BRCA1 and 2 using high-resolution melting curve analysis (HRMCA). Due to recurrent single nucleotide polymorphisms (SNPs), a considerable amount of sequencing work remains after HRMCA, as melting curves for SNPs and deleterious mutations may be similar....

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Detalhes bibliográficos
Main Authors: De Leeneer, Kim, Coene, Ilse, Poppe, Bruce, De Paepe, Anne, Claes, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Technical Advances
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729838/
https://ncbi.nlm.nih.gov/pubmed/19644020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2009.090032
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