TACROLIMUS REDUCES NITRIC OXIDE SYNTHASE FUNCTION BY BINDING TO FKBP RATHER THAN BY ITS CALCINEURIN EFFECT

Hypertension develops in many patients receiving the immunosuppressive drug tacrolimus (FK506). One possible mechanism for hypertension is a reduction in vasodilatory nitric oxide. We found that tacrolimus and a calcineurin autoinhibitory peptide significantly decreased vascular calcineurin activity...

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Main Authors: Cook, Leslie G., Chiasson, Valorie L., Long, Cheng, Wu, Gang-Yi, Mitchell, Brett M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729755/
https://ncbi.nlm.nih.gov/pubmed/19177155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2008.697
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