Treg Depletion–enhanced IL-2 Treatment Facilitates Therapy of Established Tumors Using Systemically Delivered Oncolytic Virus

There are several roadblocks that hinder systemic delivery of oncolytic viruses to the sites of metastatic disease. These include the tumor vasculature, which provides a physical barrier to tumor-specific virus extravasation. Although interleukin-2 (IL-2) has been used in antitumor therapy, it is as...

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Bibliographische Detailangaben
Hauptverfasser: Kottke, Timothy, Galivo, Feorillo, Wongthida, Phonphimon, Diaz, Rosa Maria, Thompson, Jill, Jevremovic, Dragan, Barber, Glen N, Hall, Geoff, Chester, John, Selby, Peter, Harrington, Kevin, Melcher, Alan, Vile, Richard G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729455/
https://ncbi.nlm.nih.gov/pubmed/18431359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.83
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