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Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
Ablation of inhibitory neurons that produce AgRP, NPY and GABA in the arcuate nucleus (ARC) of adult mice results in starvation within ∼ 6 days. Viral-mediated inactivation of GABA biosynthesis in the ARC also promotes anorexia. Chronic subcutaneous delivery of bretazenil (a GABA(A) receptor partial...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2729323/ https://ncbi.nlm.nih.gov/pubmed/19563755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.04.022 |
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