Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implication

Germline mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks (DSBs). Here, we describe the involvement of BRCA2 in O(6)-alkylguanine DNA alkyltransferase (AGT)—mediated repair of O(6)-methylguanine (O(6)-mG) a...

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Detalhes bibliográficos
Main Authors: Philip, Subha, Swaminathan, Srividya, Kuznetsov, Sergey G., Kanugula, Sreenivas, Biswas, Kajal, Chang, Suhwan, Loktionova, Natalia A., Haines, Diana C., Kaldis, Philipp, Pegg, Anthony E., Sharan, Shyam K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729200/
https://ncbi.nlm.nih.gov/pubmed/19047179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1179
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