A role for the TGFβ-Par6 polarity pathway in breast cancer progression

The role of polarity signaling in cancer metastasis is ill defined. Using two three-dimensional culture models of mammary epithelial cells and an orthotopic mouse model of breast cancer, we reveal that Par6 signaling, which is regulated directly by TGFβ, plays a role in breast cancer metastasis. Int...

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Bibliografske podrobnosti
Main Authors: Viloria-Petit, Alicia M., David, Laurent, Jia, Jun Yong, Erdemir, Tuba, Bane, Anita L., Pinnaduwage, Dushanthi, Roncari, Luba, Narimatsu, Masahiro, Bose, Rohit, Moffat, Jason, Wong, John W., Kerbel, Robert S., O'Malley, Frances P., Andrulis, Irene L., Wrana, Jeffrey L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729014/
https://ncbi.nlm.nih.gov/pubmed/19667198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906796106
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