BACE1 Knock-Outs Display Deficits in Activity-Dependent Potentiation of Synaptic Transmission at Mossy Fiber to CA3 Synapses in the Hippocampus

β-Amyloid precursor protein cleavage enzyme 1 (BACE1) has been identified as a major neuronal β-secretase critical for the formation of β-amyloid (Aβ) peptide, which is thought responsible for the pathology of Alzheimer's disease (AD). Therefore, BACE1 is one of the key therapeutic targets that...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wang, Hui, Song, Lihua, Laird, Fiona, Wong, Philip C., Lee, Hey-Kyoung
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2008
Gaiak:
Brief Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728626/
https://ncbi.nlm.nih.gov/pubmed/18753368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2440-08.2008
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