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Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

Cancer cells activate the biosynthesis of saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) in order to sustain an increasing demand for phospholipids with appropriate acyl composition during cell replication. We have previously shown that a stable knockdown of stearoyl-CoA desatura...

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Sonraí Bibleagrafaíochta
Main Authors: Scaglia, Natalia, Chisholm, Jeffrey W., Igal, R. Ariel
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728543/
https://ncbi.nlm.nih.gov/pubmed/19710915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006812
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