Anxiogenic-Like Behavioral Phenotype of Mice Deficient in Phosphodiesterase 4B (PDE4B)

Phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic AMP and plays a critical role in controlling its intracellular concentration, has been implicated in depression- and anxiety-like behaviors. However, the functions of the four PDE4 subfamilies (PDE4A, PDE4B, PDE4C, and PDE...

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Detalhes bibliográficos
Main Authors: Zhang, Han-Ting, Huang, Ying, Masood, Anbrin, Stolinski, Lisa R, Li, Yunfeng, Zhang, Lei, Dlaboga, Daniel, Jin, S-L Catherine, Conti, Marco, O’Donnell, James M
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728355/
https://ncbi.nlm.nih.gov/pubmed/17700644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.npp.1301537
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