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Age-related Changes in Lck-Vav Signaling Pathways in Mouse CD4 T Cells
Activation of lck-fyn kinases during T cell receptor signaling leads to Vav phosphorylation, activation of downstream targets including Rac1, and a transient decline in ezrin and moesin phosphorylation. We have shown that age increases Rac1 activity and lowers ezrin and moesin phosphorylation in res...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2728147/ https://ncbi.nlm.nih.gov/pubmed/19577230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2009.06.001 |
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