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A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists

In monkeys proficient in the performance of a computer-assisted delayed response task, administration of sub-sedative doses of ketamine significantly impaired task performance after the 2 mg/kg dose, producing a decrease in accuracies across all four delay intervals. Ketamine elicited occasional and...

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Detalhes bibliográficos
Main Authors: Buccafusco, Jerry J., Terry, Alvin V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728139/
https://ncbi.nlm.nih.gov/pubmed/19577545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.06.102
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