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Selective Deletion of the A1 Adenosine Receptor Abolishes Heart-Rate Slowing Effects of Intravascular Adenosine In Vivo

OBJECTIVE: Intravenous adenosine induces temporary bradycardia. This is due to the activation of extracellular adenosine receptors (ARs). While adenosine can signal through any of four ARs (A1AR, A2AAR, A2BAR, A3AR), previous ex vivo studies implicated the A1AR in the heart-rate slowing effects. Her...

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Bibliographic Details
Main Authors: Koeppen, Michael, Eckle, Tobias, Eltzschig, Holger K.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727950/
https://ncbi.nlm.nih.gov/pubmed/19707555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006784
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