Human melanoma cytolysis by combined inhibition of mTOR and VEGF/VEGFR-2

Vascular endothelial growth factor (VEGF) plays a vital role in tumor angiogenesis. VEGF is produced by human melanomas, and the VEGF receptor 2 (VEGFR-2) is expressed by most advanced stage melanomas, suggesting the possibility of an autocrine loop. Here we show that bevacizumab, an anti-VEGF antib...

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Hlavní autoři: Molhoek, Kerrington R., Griesemann, Heinrich, Shu, Jianfen, Gershenwald, Jeffrey E., Brautigan, David L., Slingluff, Craig L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727753/
https://ncbi.nlm.nih.gov/pubmed/18519701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-5844
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