Primary cilia regulate Shh activity in the control of molar tooth number

Primary cilia mediate Hh signalling and mutations in their protein components affect Hh activity. We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, Shh activity is increased in the toothless diastema mesenchyme of the embryonic jaw primordia. This results...

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Bibliografiska uppgifter
Huvudupphovsmän: Ohazama, Atsushi, Haycraft, Courtney J., Seppala, Maisa, Blackburn, James, Ghafoor, Sarah, Cobourne, Martyn, Martinelli, David C., Fan, Chen-Ming, Peterkova, Renata, Lesot, Herve, Yoder, Bradley K., Sharpe, Paul T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Company of Biologists 2009
Ämnen:
Research Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727556/
https://ncbi.nlm.nih.gov/pubmed/19211681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.027979
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