Primary cilia regulate Shh activity in the control of molar tooth number

Primary cilia mediate Hh signalling and mutations in their protein components affect Hh activity. We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, Shh activity is increased in the toothless diastema mesenchyme of the embryonic jaw primordia. This results...

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Bibliographische Detailangaben
Hauptverfasser: Ohazama, Atsushi, Haycraft, Courtney J., Seppala, Maisa, Blackburn, James, Ghafoor, Sarah, Cobourne, Martyn, Martinelli, David C., Fan, Chen-Ming, Peterkova, Renata, Lesot, Herve, Yoder, Bradley K., Sharpe, Paul T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2009
Schlagworte:
Research Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727556/
https://ncbi.nlm.nih.gov/pubmed/19211681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.027979
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