Primary cilia regulate Shh activity in the control of molar tooth number

Primary cilia mediate Hh signalling and mutations in their protein components affect Hh activity. We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, Shh activity is increased in the toothless diastema mesenchyme of the embryonic jaw primordia. This results...

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Autors principals: Ohazama, Atsushi, Haycraft, Courtney J., Seppala, Maisa, Blackburn, James, Ghafoor, Sarah, Cobourne, Martyn, Martinelli, David C., Fan, Chen-Ming, Peterkova, Renata, Lesot, Herve, Yoder, Bradley K., Sharpe, Paul T.
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2009
Matèries:
Research Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727556/
https://ncbi.nlm.nih.gov/pubmed/19211681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.027979
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