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Mutations in the Hepatitis C Virus Polymerase That Increase RNA Binding Can Confer Resistance to Cyclosporine A
Hepatitis C virus (HCV) infection leads to acute and chronic liver diseases, and new classes of anti-HCV therapeutics are needed. Cyclosporine A (CsA) inhibits HCV replication, and CsA derivatives that lack the immunosuppressive function are currently in clinical trials as candidate anti-HCV drugs....
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2727352/ https://ncbi.nlm.nih.gov/pubmed/19489073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22987 |
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