Mutations in the Hepatitis C Virus Polymerase That Increase RNA Binding Can Confer Resistance to Cyclosporine A

Hepatitis C virus (HCV) infection leads to acute and chronic liver diseases, and new classes of anti-HCV therapeutics are needed. Cyclosporine A (CsA) inhibits HCV replication, and CsA derivatives that lack the immunosuppressive function are currently in clinical trials as candidate anti-HCV drugs....

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Bibliographic Details
Main Authors: Liu, Zhe, Robida, John M., Chinnaswamy, Sreedhar, Yi, Guanghui, Robotham, Jason M., Nelson, Heather B., Irsigler, Andre, Kao, C. Cheng, Tang, Hengli
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727352/
https://ncbi.nlm.nih.gov/pubmed/19489073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22987
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