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Non-human primate immune libraries combined with germline humanization: An (almost) new, and powerful approach for the isolation of therapeutic antibodies

Panning of libraries constructed from immunised non-human primates (NHP) has not been widely used, even though this has proven to be a successful approach for the isolation of human-like antibody fragments with affinities in the nanomolar to the picomolar range. As recently demonstrated, after initi...

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Bibliografske podrobnosti
Main Authors: Pelat, Thibaut, Thullier, Philippe
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726609/
https://ncbi.nlm.nih.gov/pubmed/20068407
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