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Human immunoglobulin allotypes: Possible implications for immunogenicity

More than twenty recombinant monoclonal antibodies are approved as therapeutics. Almost all of these are based on the whole IgG isotype format, but vary in the origin of the variable regions between mouse (chimeric), humanized mouse and fully human sequences; all of those with whole IgG format emplo...

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Bibliografiske detaljer
Main Authors: Jefferis, Roy, Lefranc, Marie-Paule
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726606/
https://ncbi.nlm.nih.gov/pubmed/20073133
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