Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in Apc(Min/+) mice with natural ligands

Intestinal cancer is one of the most common human cancers. Aberrant activation of the canonical Wnt signaling cascade, for example, caused by adenomatous polyposis coli (APC) gene mutations, leads to increased stabilization and accumulation of β-catenin, resulting in initiation of intestinal carcino...

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Main Authors: Kawajiri, Kaname, Kobayashi, Yasuhito, Ohtake, Fumiaki, Ikuta, Togo, Matsushima, Yoshibumi, Mimura, Junsei, Pettersson, Sven, Pollenz, Richard S., Sakaki, Toshiyuki, Hirokawa, Takatsugu, Akiyama, Tetsu, Kurosumi, Masafumi, Poellinger, Lorenz, Kato, Shigeaki, Fujii-Kuriyama, Yoshiaki
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726415/
https://ncbi.nlm.nih.gov/pubmed/19651607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902132106
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