Increased c-Jun Expression and Reduced GATA2 Expression Promote Aberrant Monocytic Differentiation Induced by Activating PTPN11 Mutants

Juvenile myelomonocytic leukemia (JMML) is characterized by myelomonocytic cell overproduction and commonly bears activating mutations in PTPN11. Murine hematopoietic progenitors expressing activating Shp2 undergo myelomonocytic differentiation, despite being subjected to conditions that normally su...

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Autori principali: Yang, Zhenyun, Kondo, Takako, Voorhorst, Cara S., Nabinger, Sarah C., Ndong, Leila, Yin, Fuqin, Chan, Edward M., Yu, Menggang, Würstlin, Oliver, Kratz, Christian P., Niemeyer, Charlotte M., Flotho, Christian, Hashino, Eri, Chan, Rebecca J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725726/
https://ncbi.nlm.nih.gov/pubmed/19528235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01330-08
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