Brains with Medial Temporal Lobe Neurofibrillary Tangles But No Neuritic Amyloid Plaques Are a Diagnostic Dilemma But May Have Pathogenetic Aspects Distinct from Alzheimer Disease

Brains that have many neurofibrillary tangles (NFTs) in medial temporal lobe structures (Braak Stages III or IV) but no cortical neuritic plaques (NPs) may be a diagnostic dilemma; they also raise questions about the “amyloid cascade hypothesis” of Alzheimer disease (AD) in which NFT development is...

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Detalhes bibliográficos
Main Authors: Nelson, Peter T., Abner, Erin L., Schmitt, Frederick A., Kryscio, Richard J., Jicha, Gregory A., Santacruz, Karen, Smith, Charles D., Patel, Ela, Markesbery, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725359/
https://ncbi.nlm.nih.gov/pubmed/19535994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3181aacbe9
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