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Combinatorial probabilistic chromatin interactions produce transcriptional heterogeneity

Gene regulation often appears deterministic in the average cell population, but transcription is a probabilistic process at the single-cell level. Although many mechanisms are invoked to account for this behavior, it is difficult to determine how cell-to-cell variation in the interactions of transcr...

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Detalhes bibliográficos
Main Authors: Voss, Ty C., Schiltz, R. Louis, Sung, Myong-Hee, Johnson, Thomas A., John, Sam, Hager, Gordon L.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724732/
https://ncbi.nlm.nih.gov/pubmed/19126674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.035865
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