Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin

Dysfunction of alsin, particularly its putative Rab5 guanine-nucleotide-exchange factor activity, has been linked to one form of juvenile onset recessive familial amyotrophic lateral sclerosis (ALS2). Multiple lines of alsin knockout (ALS2(-/-)) mice have been generated to model this disease. Howeve...

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Bibliografiska uppgifter
Huvudupphovsmän: Lai, Chen, Xie, Chengsong, Shim, Hoon, Chandran, Jayanth, Howell, Brian W, Cai, Huaibin
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2009
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724476/
https://ncbi.nlm.nih.gov/pubmed/19630956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-2-23
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