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Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing

A single tumor may contain cells with different somatic mutations. By characterizing this genetic heterogeneity within tumors, advances have been made in the prognosis, treatment and understanding of tumorigenesis. In contrast, the extent of epigenetic intra-tumor heterogeneity and how it influences...

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Autori principali: Varley, Katherine E., Mutch, David G., Edmonston, Tina B., Goodfellow, Paul J., Mitra, Robi D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724279/
https://ncbi.nlm.nih.gov/pubmed/19494183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp457
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