PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

Mutations in PINK1 cause autosomal recessive Parkinson's disease. PINK1 is a mitochondrial kinase of unknown function. We investigated calcium homeostasis and mitochondrial function in PINK1-deficient mammalian neurons. We demonstrate physiologically that PINK1 regulates calcium efflux from the...

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Hlavní autoři: Gandhi, Sonia, Wood-Kaczmar, Alison, Yao, Zhi, Plun-Favreau, Helene, Deas, Emma, Klupsch, Kristina, Downward, Julian, Latchman, David S., Tabrizi, Sarah J., Wood, Nicholas W., Duchen, Michael R., Abramov, Andrey Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724101/
https://ncbi.nlm.nih.gov/pubmed/19285945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.02.013
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