Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition

Matriptase, a transmembrane serine protease, is broadly expressed by, and crucial for the integrity of, the epithelium. Matriptase is synthesized as a zymogen and undergoes autoactivation to become an active protease that is immediately inhibited by, and forms complexes with, hepatocyte growth facto...

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Main Authors: Wang, Jehng-Kang, Lee, Ming-Shyue, Tseng, I-Chu, Chou, Feng-Pai, Chen, Ya-Wen, Fulton, Amy, Lee, Herng-Sheng, Chen, Cheng-Jueng, Johnson, Michael D., Lin, Chen-Yong
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2009
Teme:
Protein and Vesicle Trafficking, Cytoskeleton
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724094/
https://ncbi.nlm.nih.gov/pubmed/19535514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00201.2009
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