Association between CCND1 G/A870 polymorphism, allele-specific amplification, cyclin D1 expression and survival in esophageal and lung carcinoma

PURPOSE: Cyclin D1 (D1) is found on 11q13 which is a region frequently amplified in several tumor types. The CCND1 locus gives rise to at least two protein isoforms of D1 (D1a and D1b). A common G/A polymorphism (G/A870) is thought to influence the expression levels of D1a and D1b. D1b has been sugg...

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Main Authors: Gupta, Vanita K., Feber, Andrew, Xi, Liqiang, Pennathur, Arjun, Wu, Maoxin, Luketich, James D, Godfrey, Tony E.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723959/
https://ncbi.nlm.nih.gov/pubmed/19047108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0744
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