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The Structure of the Cataract-Causing P23T Mutant of Human γD-Crystallin Exhibits Distinctive Local Conformational and Dynamic Changes†,‡
[Image: see text] Crystallins are major proteins of the eye lens and essential for lens transparency. Mutations and aging of crystallins cause cataracts, the predominant cause of blindness in the world. In human γD-crystallin, the P23T mutant is associated with congenital cataracts. Until now, no at...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical Society
2009
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2722838/ https://ncbi.nlm.nih.gov/pubmed/19216553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802292q |
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