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HDAC4 inhibits cell cycle progression and protects neurons from cell death

HDAC4 is a Class II histone deacetylase (HDAC) that is highly expressed in the brain but whose functional significance in the brain is not known. We show that forced expression of HDAC4 in cerebellar granule neurons protects them against low potassium-induced apoptosis. HDAC4 also partially protects...

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Detalhes bibliográficos
Main Authors: Majdzadeh, Nazanin, Wang, Lulu, Morrison, Brad E., Bassel-Duby, Rhonda, Olson, Eric N., D’Mello, Santosh R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722383/
https://ncbi.nlm.nih.gov/pubmed/18498087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dneu.20637
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