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Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis
Despite the growing interest in the Fhit tumor suppressor protein, frequently deleted in human cancers, the mechanism of its powerful proapoptotic activity has remained elusive. We here demonstrate that Fhit sensitizes the low-affinity Ca(2+) transporters of mitochondria, enhancing Ca(2+) uptake int...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2722368/ https://ncbi.nlm.nih.gov/pubmed/19622739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906484106 |
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