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Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis
Despite the growing interest in the Fhit tumor suppressor protein, frequently deleted in human cancers, the mechanism of its powerful proapoptotic activity has remained elusive. We here demonstrate that Fhit sensitizes the low-affinity Ca(2+) transporters of mitochondria, enhancing Ca(2+) uptake int...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2722368/ https://ncbi.nlm.nih.gov/pubmed/19622739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906484106 |
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