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Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase
The conventional DNA polymerase machinery is unable to fully replicate the ends of linear chromosomes. To surmount this problem, nearly all eukaryotes use the telomerase enzyme, a specialized reverse transcriptase that utizes its own RNA template to add short TG-rich repeats to chromosome ends, thus...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2722252/ https://ncbi.nlm.nih.gov/pubmed/19629031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.195 |
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