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Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component

Limb-girdle muscular dystrophy type 2H (LGMD2H) and sarcotubular myopathy are hereditary skeletal muscle disorders caused by mutations in TRIM32. We previously identified TRIM32 as an E3 ubiquitin ligase that binds to myosin and ubiquitinates actin. To date four TRIM32 mutations have been linked to...

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Bibliografiske detaljer
Main Authors: Kudryashova, Elena, Wu, Jun, Havton, Leif A., Spencer, Melissa J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722196/
https://ncbi.nlm.nih.gov/pubmed/19155210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp036
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