Long-term expression of γ-globin mRNA in mouse erythrocytes from retrovirus vectors containing the human γ-globin gene fused to the ankyrin-1 promoter

Gene therapy for patients with hemoglobin disorders has been hampered by the inability of retrovirus vectors to transfer globin genes and their cis-acting regulatory sequences into hematopoietic stem cells without rearrangement. In addition, the expression from intact globin gene vectors has been va...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Sabatino, Denise E., Seidel, Nancy E., Aviles-Mendoza, Guillermo J., Cline, Amanda P., Anderson, Stacie M., Gallagher, Patrick G., Bodine, David M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27218/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11069298/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.230453097
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