Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate

GATA-1 and PU.1 are essential hematopoietic transcription factors that control erythromegakaryocytic and myelolymphoid differentiation, respectively. These proteins antagonize each other through direct physical interaction to repress alternate lineage programs. We used immortalized Gata1(−) erythrom...

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Bibliographische Detailangaben
Hauptverfasser: Chou, Stella T., Khandros, Eugene, Bailey, L. Charles, Nichols, Kim E., Vakoc, Christopher R., Yao, Yu, Huang, Zan, Crispino, John D., Hardison, Ross C., Blobel, Gerd A., Weiss, Mitchell J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2009
Schlagworte:
Hematopoiesis and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721792/
https://ncbi.nlm.nih.gov/pubmed/19491391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-207944
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