Inhalation Dosimetry Modeling with Decamethylcyclopentasiloxane in Rats and Humans

Decamethylcyclopentasiloxane (D(5)), a volatile cyclic methyl siloxane (VCMS), is used in industrial and consumer products. Inhalation pharmacokinetics of another VCMS, octamethylcyclotetrasiloxane (D(4)), have been extensively investigated and successfully modeled with a multispecies physiologicall...

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Autors principals: Reddy, Micaela B., Dobrev, Ivan D., McNett, Debra A., Tobin, Joseph M., Utell, Mark J., Morrow, Paul E., Domoradzki, Jeanne Y., Plotzke, Kathleen P., Andersen, Melvin E.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2008
Matèries:
Biotransformation and Toxicokinetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721671/
https://ncbi.nlm.nih.gov/pubmed/18583370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn125
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