PKCα TUMOR SUPPRESSION IN THE INTESTINE IS ASSOCIATED WITH TRANSCRIPTIONAL AND TRANSLATIONAL INHIBITION OF CYCLIN D1

Alterations in PKC isozyme expression and aberrant induction of cyclin D1 are early events in intestinal tumorigenesis. Previous studies have identified cyclin D1 as a major target in the antiproliferative effects of PKCα in non-transformed intestinal cells; however, a link between PKC signaling and...

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Auteurs principaux: Pysz, Marybeth A., Leontieva, Olga V., Bateman, Nicholas W., Uronis, Joshua M., Curry, Kathryn J., Threadgill, David W., Janssen, Klaus-Peter, Robine, Sylvie, Velcich, Anna, Augenlicht, Leonard, Black, Adrian R., Black, Jennifer D.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721478/
https://ncbi.nlm.nih.gov/pubmed/19232344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2009.02.002
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