An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases

The COP9 signalosome (CSN) is an evolutionarily conserved macromolecular complex that interacts with cullin-RING E3 ligases (CRLs) and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The CSN sequesters inactive CRL4(Ddb2), which rapidly dissociates from the CSN upon DNA damage. Here...

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Bibliografiske detaljer
Main Authors: Olma, Michael Hans, Roy, Marcia, Le Bihan, Thierry, Sumara, Izabela, Maerki, Sarah, Larsen, Brett, Quadroni, Manfredo, Peter, Matthias, Tyers, Mike, Pintard, Lionel
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720933/
https://ncbi.nlm.nih.gov/pubmed/19295130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.043539
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