Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

Structure-specific endonucleases mediate repair of DNA structures formed from replication fork collapse or during double-strand break (DSB) repair. Here we identify BTBD12 as the human ortholog of the budding yeast DNA repair factor Slx4p and D. melanogaster MUS312. Human SLX4 forms a multiprotein c...

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Autori principali: Svendsen, Jennifer M., Smogorzewska, Agata, Sowa, Mathew E., O’Connell, Brenda C., Gygi, Steven P., Elledge, Stephen J., Harper, J. Wade
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720686/
https://ncbi.nlm.nih.gov/pubmed/19596235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.06.030
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