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Loss of the Putative Catalytic Domain of HDAC4 Leads to Reduced Thermal Nociception and Seizures while Allowing Normal Bone Development

Histone deacetylase 4 (HDAC4) has been associated with muscle & bone development [1]–[6]. N-terminal MEF2 and RUNX2 binding domains of HDAC4 have been shown to mediate these effects in vitro. A complete gene knockout has been reported to result in premature ossification and associated defects re...

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Detalhes bibliográficos
Main Authors: Rajan, Indrani, Savelieva, Katerina V., Ye, Gui-Lan, Wang, Ching-yun, Malbari, Murtaza M., Friddle, Carl, Lanthorn, Thomas H., Zhang, Wandong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720538/
https://ncbi.nlm.nih.gov/pubmed/19672313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006612
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