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An Ezrin/Calpain/PI3K/AMPK/eNOS(s1179) Signaling Cascade Mediating VEGF-dependent Endothelial Nitric Oxide Production
Calpain was recently reported to mediate VEGF-induced angiogenesis. In the current study we investigated detailed molecular mechanisms. VEGF (100 ng/ml) induced a marked increase in endothelial cell production of NO(•), specifically detected by electron spin resonance. This response was abolished by...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2720268/ https://ncbi.nlm.nih.gov/pubmed/19038867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.178467 |
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