Episodic Src activation in uveal melanoma revealed by kinase activity profiling

BACKGROUND: The RAS/RAF/MEK/ERK pathway is involved in the balance between melanocyte proliferation and differentiation. The same pathway is constitutively activated in cutaneous and uveal melanoma (UM) and related to tumour growth and survival. Whereas mutant BRAF and NRAS are responsible for the a...

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Detalhes bibliográficos
Main Authors: Maat, W, Filali, M el, Mulder, A Dirks-, Luyten, G P M, Gruis, N A, Desjardins, L, Boender, P, Jager, M J, van der Velden, P A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720193/
https://ncbi.nlm.nih.gov/pubmed/19568237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605172
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