Episodic Src activation in uveal melanoma revealed by kinase activity profiling

BACKGROUND: The RAS/RAF/MEK/ERK pathway is involved in the balance between melanocyte proliferation and differentiation. The same pathway is constitutively activated in cutaneous and uveal melanoma (UM) and related to tumour growth and survival. Whereas mutant BRAF and NRAS are responsible for the a...

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Detaylı Bibliyografya
Asıl Yazarlar: Maat, W, Filali, M el, Mulder, A Dirks-, Luyten, G P M, Gruis, N A, Desjardins, L, Boender, P, Jager, M J, van der Velden, P A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2009
Konular:
Molecular Diagnostics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720193/
https://ncbi.nlm.nih.gov/pubmed/19568237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605172
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