OXIDATIVE STRESS IS INDUCED BY ISLET AMYLOID FORMATION AND TIME-DEPENDENTLY MEDIATES AMYLOID-INDUCED BETA CELL APOPTOSIS

AIMS/HYPOTHESIS: Islet amyloid in type 2 diabetes contributes to loss of beta cell mass and function. Since islets are susceptible to oxidative stress-induced toxicity, we sought to determine whether islet amyloid formation is associated with induction of oxidative stress. METHODS: Human islet amylo...

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Main Authors: Zraika, S., Hull, R.L., Udayasankar, J., Aston-Mourney, K., Subramanian, S.L., Kisilevsky, R., Szarek, W.A., Kahn, S.E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719780/
https://ncbi.nlm.nih.gov/pubmed/19148619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-008-1255-x
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