The First Propeller Domain of LRP6 Regulates Sensitivity to DKK1

The Wnt coreceptor LRP6 is required for canonical Wnt signaling. To understand the molecular regulation of LRP6 function, we generated a series of monoclonal antibodies against the extra cellular domain (ECD) of LRP6 and selected a high-affinity mAb (mAb135) that recognizes cell surface expression o...

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Bibliographic Details
Main Authors: Binnerts, Minke E., Tomasevic, Nenad, Bright, Jessica M., Leung, John, Ahn, Victoria E., Kim, Kyung-Ah, Zhan, Xiaoming, Liu, Shouchun, Yonkovich, Shirlee, Williams, Jason, Zhou, Mei, Gros, Delphine, Dixon, Melissa, Korver, Wouter, Weis, William I., Abo, Arie
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719573/
https://ncbi.nlm.nih.gov/pubmed/19477926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-12-1252
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