Human variant Creutzfeldt–Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein

The pathological isoform of the prion protein (PrP(res)) can serve as a marker for prion diseases, but more practical tests are needed for preclinical diagnosis and sensitive detection of many prion infections. Previously we showed that the quaking-induced conversion (QuIC) assay can detect sub-femt...

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Main Authors: Orrú, Christina D., Wilham, Jason M., Hughson, Andrew G., Raymond, Lynne D., McNally, Kristin L., Bossers, Alex, Ligios, Ciriaco, Caughey, Byron
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2009
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Original articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719501/
https://ncbi.nlm.nih.gov/pubmed/19570812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp031
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