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DNA Ligases: Progress and Prospects
DNA ligases seal 5′-PO(4) and 3′-OH polynucleotide ends via three nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are essential guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal structures of D...
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| Hlavní autor: | |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719376/ https://ncbi.nlm.nih.gov/pubmed/19329793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R900017200 |
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